Caylor, Raymond

Dr. Caylor joined the Greenwood Genetic Center as Assistant Director of the Molecular Diagnostic Laboratory in 2018. Before coming to the Greenwood Genetic Center, Dr. Caylor completed his Clinical Molecular Genetics and Genomics fellowship training at Children’s Mercy Hospital, Kansas City, MO. He is a Clinical Molecular Geneticist certified by the American Board of Medical Genetics and Genomics and is a Fellow of the American College of Medical Genetics and Genomics. He is also a member of the American Society of Human Genetics.

Contact Information

Office: (864) 941-8171
Fax: (864) 941-8141
[email protected]

Education

• B.S. (Health Science) Valley City State University, Valley City, ND, 2007
• Ph.D. (Molecular, Cellular, and Developmental Biology) University of Kansas, 2014
• Postdoctoral Fellow, Department of Molecular Biosciences, University of Kansas, 2015
• Clinical Molecular Genetics and Genomics Fellow – Children’s Mercy Hospital, Kansas City, MO, 2016-2018
• Assistant Director, Molecular Diagnostic Laboratory, Greenwood Genetic Center, 2018-2022
• Associate Director, Molecular Diagnostic Laboratory, Greenwood Genetic Center, 2022-present

Selected Publications

• Fang X, Fee T, Davis J, Stolerman ES, Caylor RC. Clinical case report: mosaic ANK3 pathogenic variant in a patient with autism spectrum disorder and neurodevelopmental delay. Cold Spring Harb Mol Case Stud. 2023 Jul 11;9(3):a006233. doi: 10.1101/mcs.a006233. PMID: 37263801.
• Caylor RC. Nonrandom X Chromosome Inactivation Detection. Curr Protoc. 2023 Apr;3(4):e748. doi: 10.1002/cpz1.748. PMID: 37074091.
• Haghshenas S, Foroutan A, Bhai P, Levy MA, Relator R, Kerkhof J, McConkey H, Skinner CD, Caylor RC, Tedder ML, Stevenson RE, Sadikovic B, Schwartz CE. Identification of a DNA methylation signature for renpenning syndrome (RENS1), a spliceopathy. Eur J Hum Genet. 2023 Feb 16. doi: 10.1038/s41431-023-01313-z. Epub ahead of print. PMID: 36797465.
• van Jaarsveld RH, Reilly J, Cornips MC, Hadders MA, Agolini E, Ahimaz P, Anyane-Yeboa K, Bellanger SA, van Binsbergen E, van den Boogaard MJ, Brischoux-Boucher E, Caylor RC, Ciolfi A, van Essen TAJ, Fontana P, Hopman S, Iascone M, Javier MM, Kamsteeg EJ, Kerkhof J, Kido J, Kim HG, Kleefstra T, Lonardo F, Lai A, Lev D, Levy MA, Lewis MES, Lichty A, Mannens MMAM, Matsumoto N, Maya I, McConkey H, Megarbane A, Michaud V, Miele E, Niceta M, Novelli A, Onesimo R, Pfundt R, Popp B, Prijoles E, Relator R, Redon S, Rots D, Rouault K, Saida K, Schieving J, Tartaglia M, Tenconi R, Uguen K, Verbeek N, Walsh CA, Yosovich K, Yuskaitis CJ, Zampino G, Sadikovic B, Alders M, Oegema R. Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature. Genet Med. 2023 Jan;25(1):49-62. doi: 10.1016/j.gim.2022.09.006. Epub 2022 Nov 1. PMID: 36322151.
• McGee SR, Rajamanickam S, Adhikari S, Falayi OC, Wilson TA, Shayota BJ, Cooley Coleman JA, Skinner C, Caylor RC, Stevenson RE, Quaio CRAC, Wilke BC, Bain JM, Anyane-Yeboa K, Brown K, Greally JM, Bijlsma EK, Ruivenkamp CAL, Politi K, Arbogast LA, Collard MW, Huggenvik JI, Elsea SH, Jensik PJ. Expansion and mechanistic insights into de novo DEAF1 variants in DEAF1-associated neurodevelopmental disorders. Hum Mol Genet. 2023 Jan 13;32(3):386-401. doi: 10.1093/hmg/ddac200. PMID: 35981081.
• Sleyp Y, Valenzuela I, Accogli A, Ballon K, Ben-Zeev B, Berkovic SF, Broly M, Callaerts P, Caylor RC, Charles P, Chatron N, Cohen L, Coppola A, Cordeiro D, Cuccurullo C, Cuscó I, Janette diMonda, Duran-Romaña R, Ekhilevitch N, Fernández-Alvarez P, Gordon CT, Isidor B, Keren B, Lesca G, Maljaars J, Mercimek-Andrews S, Morrow MM, Muir AM; University of Washington Center for Mendelian Genomics; Rousseau F, Salpietro V, Scheffer IE, Schnur RE, Schymkowitz J, Souche E, Steyaert J, Stolerman ES, Vengoechea J, Ville D, Washington C, Weiss K, Zaid R, Sadleir LG, Mefford HC, Peeters H. De novo missense variants in the E3 ubiquitin ligase adaptor KLHL20 cause a developmental disorder with intellectual disability, epilepsy, and autism spectrum disorder. Genet Med. 2022 Dec;24(12):2464-2474. doi: 10.1016/j.gim.2022.08.020. Epub 2022 Oct 11. PMID: 36214804.
• Baker T, Caylor R, Wang J, Kilpatrick M, Batalis N, Wolff D, Welsh C. Neuropathologic Findings in Galloway-Mowat Syndrome 3 With a Novel OSGEP Variant. J Neuropathol Exp Neurol. 2022 Oct 18;81(11):947-949. doi: 10.1093/jnen/nlac077. PMID: 36063408.
• Fang X, Butler KM, Abidi F, Gass J, Beisang A, Feyma T, Ryther RC, Standridge S, Heydemann P, Jones M, Haas R, Lieberman DN, Marsh ED, Benke TA, Skinner S, Neul JL, Percy AK, Friez MJ, Caylor RC. Analysis of X-inactivation status in a Rett syndrome natural history study cohort. Mol Genet Genomic Med. 2022 May;10(5):e1917. doi: 10.1002/mgg3.1917. Epub 2022 Mar 23. PMID: 35318820.
• Upadia J, Walano N, Noh GS, Liu J, Li Y, Deputy S, Elliott LT, Wong J, Lee JA, Caylor RC, Andersson HC. HSD10 disease in a female: A case report and review of literature. JIMD Rep. 2021 Sep 15;62(1):35-43. doi: 10.1002/jmd2.12250. PMID: 34765396.
• Moss T, May M, Flanagan-Steet H, Caylor R, Jiang YH, McDonald M, Friez M, McConkie-Rosell A, Steet R. Severe multisystem pathology, metabolic acidosis, mitochondrial dysfunction, and early death associated with an X-linked AIFM1 variant. Cold Spring Harb Mol Case Stud. 2021 Jun 11;7(3):a006081. doi: 10.1101/mcs.a006081. PMID: 34117073.
• Thiffault I, Farrow E, Zellmer L, Berrios C, Miller N, Gibson M, Caylor R, Jenkins J, Faller D, Soden S, Saunders C. Clinical genome sequencing in an unbiased pediatric cohort. Genet Med. 2019 Feb;21(2):303-310. doi: 10.1038/s41436-018-0075-8. Epub 2018 Jul 16. PMID: 30008475.
• Thiffault I, Cadieux-Dion M, Farrow E, Caylor R, Miller N, Soden S, Saunders C. On the verge of diagnosis: Detection, reporting, and investigation of de novo variants in novel genes identified by clinical sequencing. Hum Mutat. 2018 Nov;39(11):1505-1516. doi: 10.1002/humu.23646. PMID: 30311385.
• Caylor RC, Grote L, Thiffault I, Farrow EG, Willig L, Soden S, Amudhavalli SM, Nopper AJ, Horii KA, Fleming E, Jenkins J, Welsh H, Ilyas M, Engleman K, Abdelmoity A, Saunders CJ. Incidental diagnosis of tuberous sclerosis complex by exome sequencing in three families with subclinical findings. Neurogenetics. 2018 Aug;19(3):205-213. doi: 10.1007/s10048-018-0551-y. Epub 2018 Jun 20. Erratum in: Neurogenetics. 2018 Jul 11;: PMID: 29926239.
• Caylor RC, Jin Y, Ackley BD. The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology. Neural Dev. 2013 May 10;8:10. doi: 10.1186/1749-8104-8-10. PMID: 23663262.