Lyons, Michael

Director of Clinical Services; Associate Clinical Geneticist

Lyons, Michael

Dr. Lyons is a clinical geneticist involved in the evaluation of genetic disorders in individuals of all ages. His areas of interest include telehealth, dysmorphology, single gene disorders, genetics education, and treatment of genetic disorders. He is also the the Director of Clinical Services for GGC overseeing clinical patient care across all five GGC offices.

Dr. Lyons is certified by the American Board of Medical Genetics (2005, recertified 2015) and the American Board of Pediatrics (2000, recertified 2007 and 2014). He is a fellow of the American College of Medical Genetics and the American Academy of Pediatrics. He holds membership in the American Academy of Pediatrics Section on Genetics and Birth Defects, American Society of Human Genetics, American Medical Association, Charleston County Medical Society, and the South Carolina Medical Association.

Contact Information

Office (843) 735-5084
Fax (843) 746-1002
[email protected]


  • M.D., Tufts University School of Medicine, Boston, MA, 1997
  • Pediatric Residency, David Grant Medical Center, Travis, AFB, CA, 1997-2000
  • Staff Pediatrician, United States Air Force, RAF Lakenheath, UK, 2000-2002
  • Chief of Pediatrics, United States Air Force, Charleston AFB, SC, 2002-2003
  • Medical Genetics Fellowship, Stanford University School of Medicine, Stanford, CA, 2003-2005
  • Assistant Clinical Geneticist, Greenwood Genetic Center, 2005-2014
  • Associate Clinical Geneticist, Greenwood Genetic Center, 2014-present
  • Director of Clinical Services, Greenwood Genetic Center

Selected Publications

  • Smith JA, Holden KR, Friez MJ, Jones JR, Lyons MJ. A novel familial autosomal dominant mutation in ARID1B causing neurodevelopmental delays, short stature, and dysmorphic features. Am J Med Genet A. 2016 Dec;170(12):3313-3318.
  • Molinero I, Broman-Fulks J, Lyons MJ, Matheus MG, Chaubey A, DuPont BR, Friez MJ, Skinner SA, Holden KR. Importance of genetic testing in global health during the evaluation of familial microcephaly. Clin Case Rep. 2016 Aug 26;4(10):968-71.
  • Langley KG, Brown J, Gerber RJ, Fox J, Friez MJ, Lyons M, Vergano SS. Beyond Ohdo Syndrome: A Familial Missense Mutation Broadens the MED12Spectrum. Am J Med Genet A. 2015 Sep 4 [Epub ahead of print].
  • Flöttmann R, Wagner J, Kobus K, Curry CJ, Savarirayan R, Nishimura G, Yasui N, Spranger J, Van Esch H, Lyons MJ, DuPont BR, Dwivedi A, Klopocki E, Horn D, Mundlos S, Spielmann M. Microdeletions on 6p22.3 are associated with mesomelic dysplasia Savarirayan type. J Med Genet. 2015 Jul;52(7):476-83. Epub 2015 Jun 1.
  • Bronicki LM, Redin C, Drunat S, Piton A, Lyons M, Pessemard S, Baumann C, Faivre L, Thevenon J, Rivière JB, Isidor B, Gan G, Francannet C, Willems M, Gunel M, Jones JR, Gleeson JG, Mandel JL, Stevenson RE, Friez MJ, Aylsworth AS. Ten New Cases Further Delineate the Syndromic Intellectual Disability Phenotype Caused by Mutations in DYRK1A. Eur J Hum Genet. 2015 Oct;23(11):1482-7. Epub 2015 Apr 29.
  • Dwivedi AC, Lyons MJ, Kwiatkowski K, Bartel FO, Friez MJ, Holden KR, Fung ET, DuPont BR. Clinical Utility of Chromosomal Microarray Analysis in the Diagnosis and Management of Monosomy 7 Mosaicism. Mol Cytogenet. 2014 Dec 4;7(1):93. eCollection 2014.
  • Smith AW, Holden, KR, Dwivedi A, Dupont BR, Lyons MJ. Deletion of 16q24.1 Supports a Role for the ATP2C2 Gene in Specific Language Impairment. J Child Neurol. 2015 Mar;30(4):517-21. Epub 2014 Oct 7.
  • Mooneyham KA, Holden KR, Cathey S, Dwivedi A, Dupont BR, Lyons MJ. Neurodevelopmental delays and macrocephaly in 17p13.1 microduplication syndrome. Am J Med Genet A. 2014 Nov;164(11):2887-91. Epub 2014 Aug 13.
  • Dean SJ, Holden KR, Dwivedi A, Dupont BR, Lyons MJ. Acquired microcephaly in blepharophimosis-ptosis-epicanthus inversus syndrome because of an interstitial 3q22.3q23 deletion. Pediatr Neurol. 2014 Jun;50(6):636-9.
  • Zarate YA, Dwivedi A, Bartel FO, Bellomo MA, Cathey SS, Champaigne NL, Clarkson LK, DuPont BR, Everman DB, Geer JS, Gordon BC, Lichty AW,Lyons MJ, Rogers RC, Saul RA, Schroer RJ, Skinner SA, Stevenson RE. Clinical utility of the X-chromosome array. Am J Med Genet. 2013 Jan;161A(1):120-30.
  • Lyons MJ, Fuller JD, Montoya MDC, DuPont BR, Holden KR. Unbalanced Translocation Involving Partial Trisomy 9p and Partial Monosomy Yq with Neurodevelopmental Delays. J Child Neurol. 2013 Apr;28(4):524-6.
  • Lockrow JP, Holden KR, Dwivedi A, Matheus MG, Lyons MJ. LIS1 Duplication: Expanding the Phenotype. J Child Neurol. 2012 Jun;27(6):791-5.
  • Veerapandiyan A, Abdul-Rahman OA, Adam MP, Lyons MJ, Manning M, Coleman K, Kobrynski L, Taneja D, Schoch K, Zimmerman HH, Shashi V. Chromosome 22q11.2 deletion syndrome in African-American patients: A diagnostic challenge. Am J Med Genet A. 2011 Sep;155(9):2186-95.
  • Edens AC, Lyons MJ, Duron RM, Dupont BR, Holden KR. Autism in two females with duplications involving Xp11.22-p11.23. Dev Med Child Neurol. 2011 May;53(5):463-6.
  • Lyons MJ, Duron R, Molinero I, Sanguiuolo F, Holden KR. Novel CLCN1mutation in carbamazepine-responsive myotonia congenita. Pediatr Neurol. 2010 May;42(5):365-8.
  • Takano K, Lyons M, Moyes C, Jones J, Schwartz CE. Two percent of patients suspected of having Angelman syndrome have TCF4 mutations. Clin Genet. 2010 Sept;78(3):282-8
  • Clark RD, Graham JM Jr, Friez MJ, Hoo JJ, Jones KL, McKeown C, Moeschler JB, Raymond FL, Rogers RC, Schwartz CE, Battaglia A,Lyons MJ, Stevenson RE. FG syndrome, an X-linked multiple congenital anomaly syndrome: The clinical phenotype and an algorithm for diagnostic testing. Genet Med. 2009 Nov;11(11):769-77.
  • Lyons MJ, Graham JM Jr, Neri G, Hunter AG, Clark RD, Rogers RC, Moscarda M, Boccuto L, Simensen R, Dodd J, Robertson S, Dupont BR, Friez MJ, Schwartz CE, Stevenson RE. Clinical experience in the evaluation of 30 patients with a prior diagnosis of FG syndrome. J Med Genet. 2009 Jan;46(1):9-13.
  • Hilton E, Johnston J, Whalen S, Okamoto N, Hatsukawa Y, Nishio J, Kohara H, Hirano Y, Mizuno S, Torii C, Kosaki K, Manouvrier S, Boute O, Perveen R, Law C, Moore A, Fitzpatrick D, Lemke J, Fellmann F, Debray FG, Dastot-Le-Moal F, Gerard M, Martin J, Bitoun P, Goossens M, Verloes A, Schinzel A, Bartholdi D, Bardakjian T, Hay B, Jenny K, Johnston K, Lyons M, et al. BCOR analysis in patients with OFCD and Lenz microphthalmia syndromes, mental retardation with ocular anomalies, and cardiac laterality defects. Eur J Hum Genet. Oct;17(10):1325-35.
  • Lyons MJ(June 2008) MED12-Related Disorders in: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2008. Available at
  • Rice G, Patric T, Parmar, R, Taylor CF, Aeby A, Aicardi J, Artuch R, Montalto SA, Bacino CA, Barroso B, Baxter P, Benko WS, Bergmann C, Bertini E, Biancheri R, Blair EM, Blau N, Bonthron DT, Briggs T, Brueton LA, Brunner HG, Burke CJ, Carr IM, Carvalho DR, Chandler KE, Christen HJ, Corry PC, Cowan FM, Cox H, D’Arrigo S, Dean J, De Laet C, De Praeter C, Dery C, Ferrie CD, Flintoff K, Frints SG, Garcia-Cazorla A, Gener B, Goizet C, Goutieres F, Green AJ, Guet A, Hamel BC, Hayward BE, Heiberg A, Hennekam RC, Husson M, Jackson AP, Jayatunga R, Jian YH, Kant SG, Kao A, King MD, Kingston HM, Klepper J, van der Knaap MS, Kornberg AJ, Kotzot D, Kratzer W, Lacombe D, Lagae L, Landrieu PG, Lanzi G, Leitch A, Lim MJ, Livingston JH, Lourenco CM, Lyall EG, Lynch SA, Lyons MJ, et al. Clinical and molecular phenotype of Aicardi-Goutieres syndrome. Am J Hum Genet. Oct;81(4):713-25.
  • Lyons MJ, Wood T, Espinoza L, Holden KR. Early Onset Alpha-Mannosidosis with mild progression in a Hispanic male. Proc Greenwood Genetic Center 25:44-47, 2006.
  • Lin RJ, Cherry AM, Chen KC, Lyons MJ, Hoyme HE, Hudgins L. Terminal deletion of 6p results in a recognizable phenotype. Am J Med Genet 136(2):162-8, 2005.

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