Yu, Seok-Ho

Dr. Yu joined Greenwood Genetic Center’s Division of Research in August 2018. His research is focused on the development and application of chemical biology technologies that are used to label and track glycoproteins in cells and tissues. This work is uncovering new molecular mechanisms underlying several genetic disorders. Before he joined Greenwood Genetic Center, he held the position of Assistant Research Scientist (non-tenure track faculty member) at the Complex Carbohydrate Research Center in University Georgia. Dr. Yu leverages his broad skills in biochemistry and chemistry towards the investigation of lysosomal storage disorders and CDGs, and other disorders of interest at GGC.

Contact Information

Education

• B.S. (Chemistry), POSTECH, Pohang, South Korea, 1993
• M.S (Organic Chemistry), POSTECH, Pohang, South Korea 1996
• Ph.D. (Bioorganic Medicinal Chemistry), POSTECH, Pohang, South Korea 2001-2005
• Postdoctoral Fellow, CALTECH, Pasadena, CA 2006-2008

Professional Appointments

• Research Scientist, Dong-Bu Research Institute, 1996-2001
• Postdoctoral Associate, UT Southwestern Medical Center 2008-2011
• Research Scientist, UT Southwestern Medical Center 2011-2013
• Research Associate, Complex Carbohydrate Research Center, University of Georgia, 2013-2016
• Assistant Research Scientist (Faculty), Complex Carbohydrate Research Center, University of Georgia, 2016-2018

Selected Publications

• Yu, S. H.; Zhao, P.; Prabhakar P.K.; Su, T.; Beedle, A.; Boons, G.-J.; Moremen, K. W.; Wells, L.; Steet, R. Defective mucin-type glycosylation on α-dystroglycan in COG-deficient cells increases its susceptibility to bacterial proteases., J Biol Chem 2018, RA118.003014
• Clifford A. Toleman, Maria A. Schumacher, Seok-Ho Yu, Wenjie Zeng, Nathan J. Cox, Timothy J. Smith, Erik J. Soderblom, Amberlyn M. Wands, Jennifer J. Kohler, and Michael Boyce., Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc Natl Acad Sci U S A 2018, 115, 5956-5961.
• Aarnio-Peterson, M.; Zhao P.; Yu, S.H.; Christian, C.; Flanagan-Steet, H.; Wells, L.; Steet, R., Altered Met receptor phosphorylation and LRP1-mediated uptake in cells lacking carbohydrate-dependent lysosomal targeting, J Biol Chem 2017, 292, 15094-15104.
• Yu, S. H. *; Su, T *; Zhao, P.*; Meng L.; Moremen, K. W.; Wells, L.; Steet, R.; Boons, G.-J., A one-step selective exo-enzymatic labeling (SEEL) strategy for the biotinylation and identification of glycoproteins of living cells, J Am Chem Soc, 2016, 138(36), 11575-11582. (*Co-first Authors)
• Yu, S. H.; Zhao, P.; Su, T; Gao, Z.; Moremen, K. W.; Boons, G.-J.; Wells, L.; Steet, R. Selective Exo-Enzymatic Labeling Detects Increased Cell Surface Sialoglycoprotein Expression Upon Megakaryocytic Differentiation, J Biol Chem 2016, 291, 3982-3989.
• Yu, S. H.; Rodriguez, A*.; Li, B.; Zegzouti, H.; Kohler, J. J., Enhanced Transfer of a Photocross-linking N-Acetylglucosamine (GlcNAc) Analog by an O-GlcNAc Transferase Mutant with Converted Substrate Specificity, J Biol Chem 2015, 290, 22638-22648. (*Co-first Authors)
• Yu, S. H.; Boyce, M.; Wands, A. M.; Bond, M. R.; Bertozzi, C. R.; Kohler, J. J., Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners. Proc Natl Acad Sci U S A 2012, 109, 4834-4839. “Binders of O-Glycosylated proteins”, Nat Methods 2012, 9, 435. Eva J. Gordon, “Cross-linking O-Linked Glycosylation”, ACS Chem Biol 2012,7, 620–622.
• Boyce, M.; Carrico, I. S.; Ganguli, A. S.; Yu, S. H.; Hangauer, M. J.; Hubbard, S. C.; Kohler, J. J.; Bertozzi, C. R., Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway. Proc Natl Acad Sci U S A 2011, 108, 3141-3146.
• Rexach, J. E.; Rogers, C. J.; Yu, S. H.; Tao, J.; Sun, Y. E.; Hsieh-Wilson, L. C., Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags. Nat Chem Biol 2010, 6, 645-51.