Should I get NIPS if I have a family history of birth defects? What about a family history of cystic fibrosis?

Standard NIPS only screens for Down syndrome (trisomy 21), trisomy 13, trisomy 18, Turner syndrome (monosomy X), Klinefelter syndrome (XXY), and other possible sex chromosome differences. Most birth defects are not caused by these conditions. Therefore, a negative NIPS cannot identify your risk for other birth defects or genetic conditions.