GGC Receives Funding for Alzheimer's Project

10.03.23

GGC has received funding in the South Carolina state budget for the Carroll A. Campbell, Jr. Alzheimer’s Initiative. SC Governor Henry McMaster requested the funding named in honor of former SC Governor Carroll Campbell who passed away with Alzheimer’s disease in 2005. Alzheimer’s disease is the most common cause of dementia and impacts more than six million Americans.

The project is a collaboration between GGC; MitoSense, a research and development biotechnology company; and the US Veteran’s Administration to assess a potential therapy for Alzheimer’s disease aimed at improving energy production in brain cells.

The brain requires very high amounts of energy for normal activity. This energy is produced by the mitochondria, the powerhouses of the cell. Patients with Alzheimer’s disease show dysfunction of the mitochondria, specifically in their brain cells, which leads to reduced energy production and is believed to be related to degeneration of those brain cells and disease progression.

MitoSense has developed a technology to replenish mitochondria through Mitochondria Organelle Transplantation (MOT™️). The process places healthy mitochondria into cells with depleted or ineffective mitochondria. The goal is to improve the energy production within the cells leading to better cellular function, reduced symptoms, and slower progression of the disease.

“This is GGC’s first significant involvement in Alzheimer’s disease research,” said Rich Steet, PhD, GGC’s Director of Research who is leading GGC’s part of the project. “We are excited about the potential of this new technology and anticipate that it could be a significant advancement for patients with Alzheimer’s disease, and might also benefit our pediatric patients who have rare disorders caused by mitochondrial dysfunction.”

Mom looking at daughter

Meet Esther

Esther was referred to GGC around a year of age after her parents and pediatrician identified concerns with her development. She was diagnosed with Rett syndrome by Dr. David Everman of GGC's Greenville office. GGC is a Rett Syndrome Center of Excellence and has been caring for Esther ever since her diagnosis. Meet Esther, her family, and friends in this video from Special Books by Special Kids....

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