Pregnancy Loss Microarray

Test Information

The pregnancy loss microarray is performed using either Affymetrix CytoScan HD or OncoScan. This analysis can detect abnormalities such as aneuploidy, mosaicism as low as 20%, common microdeletion and microduplication syndromes, interstitial and terminal chromosome deletions and duplications greater than >300 kb, and loss of heterozygosity and suspected uniparental disomy (UPD).

Turnaround Time

26 days

CPT Code(s)

81229

Cost

$1,950

Clinical Information

Pregnancy loss occurs in up to 15% of all recognized pregnancies. In approximately half of these cases, the loss can be attributed to the presence of one or more chromosome abnormalities. The pregnancy loss microarray is performed using either Affymetrix CytoScan HD or OncoScan, and the appropriate platform will be determined by sample type and condition. This analysis can detect the following abnormalities: Aneuploidy Mosaicism as low as 20% Common microdeletion and microduplication syndromes Interstitial and terminal chromosome deletions and duplications greater than >300 kb Loss of heterozygosity and suspected uniparental disomy (UPD) If a maternal sample is also sent to the laboratory, maternal cell contamination can be detected, and the parent of origin for uniparental isodisomy can be determined.

Indications

Pregnancy loss microarray can be performed on fetal samples following miscarriage, fetal demise, or stillbirth.

Specimen Requirements

Fresh tissue (fetal tissue, amnion, placenta) Cultured cells Formalin fixed paraffin embedded (FFPE) Products of Conception should be placed in a sterile container for transport. The specimen must be kept moist, so add tissue culture media or sterile saline if needed. Fresh tissue: Using sterile technique, obtain a 5 mm biopsy of unmacerated fetal tissue and place in tube containing transport media. If tissue culture media is not available, sterile solutions such as balanced salt solution may be used. The preferred placental tissues are fetal membranes or chorionic villi. If fetal samples are obtained at autopsy, lung, gonad or thymus are preferred for chromosome study. Cultured tissue: 2-T25 confluent flasks can be sent for analysis. Extracted DNA is also accepted for this test. Please note that a maternal sample (4-5 ml of blood collected in a lavender-top/EDTA tube) is strongly recommended to rule out the presence of maternal cell contamination in POC samples. Additional specimen types include: saliva and extracted DNA. An additional charge ($350) will apply.

Transport Instructions

The specimen should be kept at room temperature and delivered via overnight shipping. Do not freeze.

Have Questions? Need Support?

Call our laboratory at 1-800-473-9411 or contact one of our Laboratory Genetic Counselors for assistance.
Robin Fletcher, MS, CGC
Falecia Thomas, MS, CGC
Alex Finley, MS, CGC

Meet Makayla Gunn

Makayla was diagnosed with Rett Syndrome in April of 2015 at the age of two. At about 18 months, we noticed she had started some repetitive hand motions, and her pediatrician was a little concerned that she did not have many words. She had learned some sign language, and was saying ‘mama’ and ‘dada’, but that was it. Then she suddenly stopped all of that. At her 2 year old check-up, the pediatrician referred us to BabyNet, SC’s early interve...

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