Chromosome Analysis (Bone Marrow)
Key Information
Lab:
TAT:
10 days
Price:
$890
CPT Code(s):
88237, 88264, 88280x2, 88291
Test Code:
CBMR
Chromosome Analysis (Bone Marrow)
Chromosome analysis on bone marrow can be used to asses remission or relapse of malignancy and/or to determine the presence or absence of abnormal clones. The finding of a normal karyotype in bone marrow cells of individuals with myelodysplastic syndrome, acute myeloid leukemia, acute lymphoblastic leukemia or lymphoproliferative disorders is generally considered to be a favorable prognostic indicator. Submission of a follow-up specimen to monitor karyotypic evolution should be considered as clinically permitted or as the clinical course changes.
Clinical Information
Chromosome analysis on bone marrow is helpful in assessing remission or relapse of malignancy in individuals with myelodysplastic syndrome, acute myeloid leukemia, acute lymphoblastic leukemia, or lymphoproliferative disorders. Bone marrow is the preferred sample type in contrast to peripheral blood.
Technical Information
A minimum of 20 cells are counted. If a peripheral blood is received along with the bone marrow, stimulated and unstimulated cultures are established. However, stimulated blood cultures are analyzed only if bone marrow cultures fail. GTW banding is performed on metaphase spreads.
Specimen Requirements
Bone marrow is the accepted sample type. Volume is dependent on availability and white count of sample necessary by calculations. Heparinized syringe samples or bone marrow collected in a sodium heparin vacutainer can be sent.
Transport Instructions
Bone marrow should be kept at room temperature and sent by courier or overnight shipping to arrive at the laboratory within 24 hours. Do not freeze or refrigerate the specimen.
Associated Tests
Connect With Our Experts
Call 1-800-473-9411 to speak with our team of laboratory genetic counselors for questions or additional information.
Robin Fletcher, MS, CGC
Falecia Thomas, MS, CGC
Alex Finley, MS, CGC