Chromosome Analysis, Routine; Rule Out Mosaic (Solid Tissue)
Key Information
Lab:
TAT:
6 weeks
Price:
$857
CPT Code(s):
88233, 88263, 88285x5, 88291
Test Code:
CTRM
Chromosome Analysis, Routine; Rule Out Mosaic (Solid Tissue)
Chromosome mosaicism is defined as the presence of two or more cell lines with different chromosome constitutions in a single individual. Chromosome analysis to rule out mosaicism from solid tissue includes routine karyotyping using G-banded preparations. This test uses a larger cell count to assess for mosaicism.
Please note that additional fees may apply if more than one tissue type is submitted. Please use a multiplier equal to the number of samples submitted for CPT Code 88233.
Clinical Information
Chromosome analysis on solid tissue can clarify if an atypical number of chromosomes is present in tissue at a lower level of mosaicism. This analysis may be indicated if chromosome analysis on blood has returned negative/normal and there is a high clinical suspicion of a chromosomal condition or in which tissue is available from a skin punch or surgery.
Technical Information
For rule out mosaic chromosome analysis, 50 cells are counted to determine the modal number and a minimum of 5 cells are analyzed for chromosomal abnormalities from G-banded preparations.
Specimen Requirements
Using a sterile technique, obtain a 5mm biopsy of unmacerated tissue and place in a tube containing transport media or a sterile solution such as a balanced salt solution. For fetal tissue, placental tissue (fetal membranes or chorionic villi) or a piece of amnion is requested in addition to the fetal specimen (for all cases). If fetal samples are obtained at autopsy, skin, gonad or thymus are preferred for chromosome analysis. DO NOT allow the specimen to come into contact with formalin or other fixatives if chromosome analysis is ordered as fixed tissue will not grow for chromosome analysis. Chromosome analysis cannot be performed on FFPE samples.
Transport Instructions
The specimen should be kept at room temperature if transported immediately. If the specimen is not being immediately transported to the laboratory, it may be refrigerated. Do not freeze. The sample should be sent by courier or overnight mail to arrive at the laboratory within 24 hours.
Associated Tests
Connect With Our Experts
Call 1-800-473-9411 to speak with our team of laboratory genetic counselors for questions or additional information.
Robin Fletcher, MS, CGC
Falecia Thomas, MS, CGC
Alex Finley, MS, CGC