Chromosome Analysis, Routine; Short Study (Solid Tissue)
Key Information
Lab:
TAT:
6 weeks
Price:
$632
CPT Code(s):
88261, 88291, 88233
Test Code:
CTSS
Chromosome Analysis, Routine; Short Study (Solid Tissue)
Short study chromosome analysis includes routine karyotyping using G-banding, but fewer cells are analyzed than with routine karyotyping. For short study chromosome analysis, a minimum of 5 cells are counted and a minimum of 2 cells are analyzed for chromosomal abnormalities. Short study chromosome analysis can be used to complement other methods such as microarray to detect certain rearrangements that can only be identified by karyotype. A karyotype can detect chromosome abnormalities such as trisomy, monosomy, triploidy, and marker chromosomes as well as balanced and unbalanced rearrangements.
Please note that additional fees may apply if more than one tissue type is submitted. Please use a multiplier equal to the number of samples submitted for CPT Code 88233.
Clinical Information
Chromosome analysis on solid tissue can clarify if an atypical number of chromosomes is present in tissue. This analysis may be indicated if chromosome analysis on blood has returned negative/normal and there is a high clinical suspicion of a chromosomal condition or in which tissue is available from a skin punch or surgery.
Technical Information
Short study chromosome analysis includes routine karyotyping using G-banding, but fewer cells are analyzed than with routine karyotyping. For short study chromosome analysis, a minimum of 5 cells are counted and a minimum of 2 cells are analyzed for chromosomal abnormalities from G-banded preparations. Short study chromosome analysis can be used to complement other methods such as microarray to detect certain rearrangements that can only be identified by karyotype.
Specimen Requirements
Using a sterile technique, obtain a 5mm biopsy of unmacerated tissue and place in a tube containing transport media or a sterile solution such as a balanced salt solution. For fetal tissue, placental tissue (fetal membranes or chorionic villi) or a piece of amnion is requested in addition to the fetal specimen (for all cases). If fetal samples are obtained at autopsy, skin, gonad or thymus are preferred for chromosome analysis. DO NOT allow the specimen to come into contact with formalin or other fixatives if chromosome analysis is ordered as fixed tissue will not grow for chromosome analysis. Chromosome analysis cannot be performed on FFPE samples.
Transport Instructions
The specimen should be kept at room temperature if transported immediately. If the specimen is not being immediately transported to the laboratory, it may be refrigerated. Do not freeze. The sample should be sent by courier or overnight mail to arrive at the laboratory within 24 hours.
Associated Tests
Connect With Our Experts
Call 1-800-473-9411 to speak with our team of laboratory genetic counselors for questions or additional information.
Robin Fletcher, MS, CGC
Falecia Thomas, MS, CGC
Alex Finley, MS, CGC